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L1 exhibits a peculiar expression pattern in EOC lesions, and exerts a cell context-dependent role, with a clear pro-malignant function. The metastatic, but not the non-metastatic cells can induce CAIX and regulate extracellular acidification under hypoxia. We also will show that upon cell contact, T cells acquire from B cells small RNAs, which impact expression of target genes in the recipient T cells. However, it still remains unknown which component of tumor microenvironment is really responsible for tumor immunopathgenity. These conclusions are mostly based on following the fate, gene expression profiles and functional performance of genetically-tagged monocytes adoptively-transferred into the circulation of mice in which VEGF has been induced in selected organs.

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Tumor progression is accompanied by a desmoplastic response that is characterized by significant extracellular matrix ECM remodeling. Our results elucidate a novel mechanism downstream of Notch3 by which the direct interplay between endothelial and tumor cells promotes survival of T-ALL cells. Multiple myeloma is a neoplasm of bone marrow resident plasma cells characterized by a critical interaction between myeloma cells and bone marrow stromal cells, which produce IL-6, supporting myeloma cell survival. Wwox suppresses the transactivation functions of several transcription factors implied in cancer by sequestering them in the cytoplasm. I was flat as a ruler.

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